The Brutlag Bioinformatics Group

eBLOCKS : eBLOCKS: Database of 80,000 conserved protein regions from 20,000 aligned protein families assembled using PSI-BLAST. eBLOCKs lets you compare new proteins to this database of conserved sequences using either eMOTIFs or eMATRICES made from eBLOCKs.

eProteome: A database of eMOTIFs, eMATRICES and protein sequence similarities found in all of the open reading frames translated from over 60 genomes. eMOTIFs, eMATRICES or sequence similarities can be selected by genome, keyword or specificity or combinations of these parameters.

3MOTIF 3MOTIF visualizes the three dimensional structure of eMOTIFs contained within structures from the Protein Structure Database (PDB). One needs the Chime plug-in to view the 3MOTIF structures. Multiple views of the structural motifs are possible.

3MATRIX visualizes the three dimensional structure of eMATRIX motifs contained within structures from the Protein Structure Database (PDB). One needs the Chime plug-in to view the 3MATRIX motif structures. Multiple views of the structural motifs are possible.

BioProspector

MDScan

BioProspector takes sets of upstream sequences of co-regulated genes from either microarray experiments or clustered microarray experiments and can discover conserved transcription factor binding sites in these upstream sequences. BioProspector uses a stochastic Gibb's sampling alignment algorithm

MDScan takes upstream sequences from either single microarray experiments or from chromatin immune precipitation experiments and can discover weakly conserved transcription factor binding sites. MDScan has nearly the same sensitivity as BioProspector but uses a deterministic algorithm which is several fold faster and does not get caught in local minima.

LOCK 2 - A vector based protein structure superposition algorithm capable of recognizing distant structural similarities. Statistical significance values for alignments are provided.

FoldMiner Performs structural similarity searches and discovers a structural motif common to the query protein and high scoring target structures. Motifs are used to improve both the sensitivity and specificity of the search by focusing on conserved portions of the structure.

Emotif-search -Compares proteins or ORFs of unknown functions against a database of sequence motifs (50,000) of varying specificities to identify functional and structural motifs in the protein.

Ematrix-search - Compares proteins or ORFs of unknown function against a series of Position Specific Scoring Matrices compiled from the BLOCKS and PRINTS databases using a very rapid and highly discriminating search procedure.

Emotif-scan - Searches the GenPept and SWISS-PROT databases for proteins containing a particular motif (or regular expression).

Ematrix-scan - eMATRIX-Scan takes a position specific scoring matrix generated by eMATRIX-Maker and Scans the Swiss-Prot database for examples of sequences that match the scoring matrix with an expectation above a specified level (default is 10-8).

Emotif-maker - Forms protein sequence motifs for subsets of aligned sequences, ranking them by both their specificity and the number of supplied sequences covered (sensitivity).

Ematrix-maker - Develops position specific scoring matrices (PSSM's) for protein motifs that permits sequence weighting, prior probabilities or pseudocounts and a variety of discriminant functions to be used in database search.

eSignal

eSignal : A database of eMOTIFs and eMATRICES generated exclusively from signal transduction proteins. ESIGNAL can be used to discover signal transduction functions in new proteins.

Decypher - Decypher is a high performance sequence database search engine from Time Logic that can perform BLAST searches (BLASTN, BLASTP, BLASTX, TBLASTN and PSI-BLAST) and dynamic programming searches (Smith Waterman, Profile, HMM) in seconds on entire databases and entire genomes.

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eBLOCKS : eBLOCKS: Database of 80,000 conserved protein regions from 20,000 aligned protein families assembled using PSI-BLAST. eBLOCKs lets you compare new proteins to this database of conserved sequences using either eMOTIFs or eMATRICES made from eBLOCKs.		eProteome: A database of eMOTIFs, eMATRICES and protein sequence similarities found in all of the open reading frames translated from over 60 genomes. eMOTIFs, eMATRICES or sequence similarities can be selected by genome, keyword or specificity or combinations of these parameters.

3MOTIF 3MOTIF visualizes the three dimensional structure of eMOTIFs contained within structures from the Protein Structure Database (PDB). One needs the Chime plug-in to view the 3MOTIF structures. Multiple views of the structural motifs are possible.		3MATRIX visualizes the three dimensional structure of eMATRIX motifs contained within structures from the Protein Structure Database (PDB). One needs the Chime plug-in to view the 3MATRIX motif structures. Multiple views of the structural motifs are possible.
*BioProspector*		*MDScan*
BioProspector takes sets of upstream sequences of co-regulated genes from either microarray experiments or clustered microarray experiments and can discover conserved transcription factor binding sites in these upstream sequences. BioProspector uses a stochastic Gibb's sampling alignment algorithm		MDScan takes upstream sequences from either single microarray experiments or from chromatin immune precipitation experiments and can discover weakly conserved transcription factor binding sites. MDScan has nearly the same sensitivity as BioProspector but uses a deterministic algorithm which is several fold faster and does not get caught in local minima.

LOCK 2 - A vector based protein structure superposition algorithm capable of recognizing distant structural similarities. Statistical significance values for alignments are provided.		FoldMiner Performs structural similarity searches and discovers a structural motif common to the query protein and high scoring target structures. Motifs are used to improve both the sensitivity and specificity of the search by focusing on conserved portions of the structure.

Emotif-search -Compares proteins or ORFs of unknown functions against a database of sequence motifs (50,000) of varying specificities to identify functional and structural motifs in the protein.		Ematrix-search - Compares proteins or ORFs of unknown function against a series of Position Specific Scoring Matrices compiled from the BLOCKS and PRINTS databases using a very rapid and highly discriminating search procedure.

Emotif-scan - Searches the GenPept and SWISS-PROT databases for proteins containing a particular motif (or regular expression).		Ematrix-scan - eMATRIX-Scan takes a position specific scoring matrix generated by eMATRIX-Maker and Scans the Swiss-Prot database for examples of sequences that match the scoring matrix with an expectation above a specified level (default is 10-8).

Emotif-maker - Forms protein sequence motifs for subsets of aligned sequences, ranking them by both their specificity and the number of supplied sequences covered (sensitivity).		Ematrix-maker - Develops position specific scoring matrices (PSSM's) for protein motifs that permits sequence weighting, prior probabilities or pseudocounts and a variety of discriminant functions to be used in database search.
*eSignal*
eSignal : A database of eMOTIFs and eMATRICES generated exclusively from signal transduction proteins. ESIGNAL can be used to discover signal transduction functions in new proteins.		Decypher - Decypher is a high performance sequence database search engine from Time Logic that can perform BLAST searches (BLASTN, BLASTP, BLASTX, TBLASTN and PSI-BLAST) and dynamic programming searches (Smith Waterman, Profile, HMM) in seconds on entire databases and entire genomes.